Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis
نویسندگان
چکیده
منابع مشابه
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.
Individual ubiquitin (Ub)-protein ligases (E3s) cooperate with specific Ub-conjugating enzymes (E2s) to modify cognate substrates with polyubiquitin chains. E3s belonging to the Really Interesting New Gene (RING) and Homologous to E6-Associated Protein (E6AP) C-Terminus (HECT) domain families utilize distinct molecular mechanisms. In particular, HECT E3s, but not RING E3s, form a thiol ester wi...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2005
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600895